ParkinsonCanadaV1, Main, Exploration, bibRecord, 001078

Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude

Identifieur interne : 001078 ( Main/Exploration ); précédent : 001077; suivant : 001079

Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude

Auteurs : Madeleine E. Sharp [Canada] ; Jayalakshmi Viswanathan [Canada] ; Martin J. Mckeown [Canada] ; Silke Appel-Cresswell [Canada] ; A. Jon Stoessl [Canada] ; Jason J. S. Barton [Canada]

Source :

Neuropsychologia [ 0028-3932 ] ; 2013.

RBID : Pascal:14-0024237

Descripteurs français

Pascal (Inist)
- Prise de décision, Prise risque, Maladie de Parkinson, Evaluation, Probabilité, Trouble du contrôle des impulsions, Homme, Personne âgée, Théorie des perspectives.
Wicri :
- topic : Prise de décision, Homme, Personne âgée.

English descriptors

KwdEn :
- Decision making, Elderly, Evaluation, Human, Impulse control disorder, Parkinson disease, Probability, Prospect theory, Risk taking.

Abstract

Introduction: Unmedicated Parkinson's disease patients tend to be risk-averse while dopaminergic treatment causes a tendency to take risks. While dopamine agonists may result in clinically apparent impulse control disorders, treatment with levodopa also causes shift in behaviour associated with an enhanced response to rewards. Two important determinants in decision-making are how subjects perceive the magnitude and probability of outcomes. Our objective was to determine if patients with Parkinson's disease on or off levodopa showed differences in their perception of value when making decisions under risk. Methods: The Vancouver Gambling task presents subjects with a choice between one prospect with larger outcome and a second with higher probability. Eighteen age-matched controls and eighteen patients with Parkinson's disease before and after levodopa were tested. In the Gain Phase subjects chose between one prospect with higher probability and another with larger reward to maximize their gains. In the Loss Phase, subjects played to minimize their losses. Results: Patients with Parkinson's disease, on or off levodopa, were similar to controls when evaluating gains. However, in the Loss Phase before levodopa, they were more likely to avoid the prospect with lower probability but larger loss, as indicated by the steeper slope of their group psychometric function (t₍₂₄₎=2.21, p=0.04). Modelling with prospect theory suggested that this was attributable to a 28% overestimation of the magnitude of loss, rather than an altered perception of its probability. Conclusion: While pre-medicated patients with Parkinson's disease show risk-aversion for large losses, patients on levodopa have normal perception of magnitude and probability for both loss and gain. The finding of accurate and normally biased decisions under risk in medicated patients with PD is important because it indicates that, if there is indeed anomalous risk-seeking behaviour in such a cohort, it may derive from abnormalities in components of decision making that are separate from evaluations of size and probability.

Affiliations:

Canada

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000044
to stream PascalFrancis, to step Corpus: 000059
to stream PascalFrancis, to step Curation: 000B74
to stream PascalFrancis, to step Checkpoint: 000089
to stream Main, to step Merge: 001096
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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Decision making</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Prise de décision</term>
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<term>Maladie de Parkinson</term>
<term>Evaluation</term>
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<front><div type="abstract" xml:lang="en">Introduction: Unmedicated Parkinson's disease patients tend to be risk-averse while dopaminergic treatment causes a tendency to take risks. While dopamine agonists may result in clinically apparent impulse control disorders, treatment with levodopa also causes shift in behaviour associated with an enhanced response to rewards. Two important determinants in decision-making are how subjects perceive the magnitude and probability of outcomes. Our objective was to determine if patients with Parkinson's disease on or off levodopa showed differences in their perception of value when making decisions under risk. Methods: The Vancouver Gambling task presents subjects with a choice between one prospect with larger outcome and a second with higher probability. Eighteen age-matched controls and eighteen patients with Parkinson's disease before and after levodopa were tested. In the Gain Phase subjects chose between one prospect with higher probability and another with larger reward to maximize their gains. In the Loss Phase, subjects played to minimize their losses. Results: Patients with Parkinson's disease, on or off levodopa, were similar to controls when evaluating gains. However, in the Loss Phase before levodopa, they were more likely to avoid the prospect with lower probability but larger loss, as indicated by the steeper slope of their group psychometric function (t<sub>(24)</sub>
=2.21, p=0.04). Modelling with prospect theory suggested that this was attributable to a 28% overestimation of the magnitude of loss, rather than an altered perception of its probability. Conclusion: While pre-medicated patients with Parkinson's disease show risk-aversion for large losses, patients on levodopa have normal perception of magnitude and probability for both loss and gain. The finding of accurate and normally biased decisions under risk in medicated patients with PD is important because it indicates that, if there is indeed anomalous risk-seeking behaviour in such a cohort, it may derive from abnormalities in components of decision making that are separate from evaluations of size and probability.</div>
</front>
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<tree><country name="Canada"><noRegion><name sortKey="Sharp, Madeleine E" sort="Sharp, Madeleine E" uniqKey="Sharp M" first="Madeleine E." last="Sharp">Madeleine E. Sharp</name>
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<name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name>
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<name sortKey="Viswanathan, Jayalakshmi" sort="Viswanathan, Jayalakshmi" uniqKey="Viswanathan J" first="Jayalakshmi" last="Viswanathan">Jayalakshmi Viswanathan</name>
<name sortKey="Viswanathan, Jayalakshmi" sort="Viswanathan, Jayalakshmi" uniqKey="Viswanathan J" first="Jayalakshmi" last="Viswanathan">Jayalakshmi Viswanathan</name>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude

Decisions under risk in Parkinson's disease: Preserved evaluation of probability and magnitude

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri